Thermo Fisher Scientific Inc. TMO

Thermo Fisher Scientific Inc., incorporated on October 11, 1960, develops, manufactures and sells a range of products. The Company provides analytical instruments, equipment, reagents and consumables, software and services for research, manufacturing, analysis, discovery and diagnostics. The Company operates through four segments: Life Sciences Solutions, Analytical Instruments, Specialty Diagnostics, and Laboratory Products and Services. The Company serves various markets, such as pharmaceutical and biotech; academic and government; industrial and applied; as well as healthcare and diagnostics. The Company serves its customers through its brands, such as Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

The Thermo Scientific brand offers customers in research, diagnostics, industrial, and applied markets a range of analytical instruments, as well as laboratory equipment, software, services, consumables and reagents. Its portfolio of products includes technologies for mass spectrometry, chromatography, elemental analysis, molecular spectroscopy, sample preparation, informatics, chemical research and analysis, cell culture, bioprocess production, cellular, protein and molecular biology research, allergy testing, drugs-of-abuse testing, therapeutic drug monitoring testing, microbiology, as well as environmental monitoring and process control. The Applied Biosystems brand offers customers in research, clinical and applied markets integrated instrument systems, reagents, and software for genetic analysis. Its portfolio includes technologies for genetic sequencing and real-time, digital and end point polymerase chain reaction (PCR), that are used to determine meaningful genetic information in applications, such as cancer diagnostics, human identification testing, and animal health, as well as inherited and infectious disease.

The Invitrogen brand offers life science customers a range of consumables and instruments. Its portfolio of products includes solutions for cellular analysis and biology, flow cytometry, cell culture, protein expression, synthetic biology, molecular biology and protein biology. The Fisher Scientific brand offers customers a portfolio of laboratory equipment, chemicals, supplies and services used in scientific research, healthcare, safety, and education markets. These products are offered through a network of direct sales professionals, industry-specific catalogs, e-commerce capabilities and supply-chain management services. It also offers a range of biopharma services for clinical trials management and biospecimen storage. The Unity Lab Services brand offers a portfolio of services from enterprise level engagements to individual instruments and laboratory equipment, regardless of the original manufacturer.

Life Sciences Solutions Segment

Through the Life Sciences Solutions segment, the Company provides a portfolio of reagents, instruments and consumables used in biological and medical research, discovery and production of new drugs and vaccines, as well as diagnosis of disease. Its product categories include cell culture and bioproduction; sample preparation and storage; liquid handling; detection instruments; and specialty products and services. Its laboratory and specialty plastics include cell culture and bioproduction products, which support customers in research to production-scale activities. The Company’s products and services are used by customers in pharmaceutical, biotechnology, agricultural, clinical, academic and government markets. As of December 31, 2016, the Life Sciences Solutions included four primary businesses: Biosciences, Genetic Sciences, Clinical Next-Generation Sequencing, and BioProduction.

The biosciences business includes reagents, instruments and consumables that help its customers conduct biological and medical research, discover new drugs and vaccines, and, in the case of some specific products, the diagnosis of disease. The biosciences offerings include reagents, instruments, and consumables used for protein biology, molecular biology, and cell imaging and analysis. The portfolio includes antibodies and products for protein purification, detection, modification, and analysis; and sequencing, detection and purification products used for content analysis of nucleic acids. It offers tools used for genetic engineering, amplification, quantification and analysis, as well as ribonucleic acid (RNA) isolation, including stem cell reprogramming kits, transfection reagents, RNA interference reagents, along with gene editing tools and gene synthesis products. It offers cell culture media and reagents for preserving and growing mammalian cells, which are used in life science research applications. It offers fluorescence-based technologies, which facilitate the labeling of molecules for biological research and drug discovery. These technologies include a range of cell analysis instruments, including flow cytometers and imaging platforms that enable fluorescence microscopy. It offers protein analysis products, including pre-cast electrophoresis gels for separating nucleic acids and proteins, and western blotting and staining tools.

The Company's genetic sciences business combines a range of instruments and related reagents used to provide genomic solutions to assist customer decisions in the research, clinical and applied markets. Its offerings include real-time PCR technology used to identify changes in gene expression, genotyping or proteins on an individual gene-by-gene basis; capillary electrophoresis (CE) sequencing, technology used in deoxyribonucleic acid (DNA) sequencing and fragment analysis applications, and microarray technology, used in gene expression, genotyping and reproductive health. Its clinical Next-Generation Sequencing (NGS) business focuses on delivering NGS technology for a range of applications. Its bioproduction business supports developers and manufacturers of biological-based therapeutics and vaccines with a portfolio of solutions and services focused on upstream cell culture, downstream purification, analytics for detection and quantitation of process/product impurities, and a suite of single-use solutions spanning the biologics workflow. Its bioproduction offerings include Single-use bioproduction solutions, production cell culture media solutions, chromatography products, molecular products and scalable solutions.

The Company's BioPharma Services offerings include global services for pharmaceutical and biotechnology companies engaged in clinical trials, including comparator sourcing; specialized packaging; over-encapsulation; multi-lingual and specialized labeling and distribution for phase I through phase IV clinical trials; biological-specimen management; specialty pharmaceutical logistics; and clinical supply-chain planning and management. Its biobanking business provides temperature-controlled repository services for pharmaceutical, biotechnology, university, government, clinical and blood-processing customers. Its biobanking services business stores pharmacological and biospecimen samples at commercial sites. Additional services include inventory management, validation, business continuity, and repository management and transportation capabilities, resulting in a complete cold chain sample management solution.

Analytical Instruments Segment

Through the Analytical Instruments segment, the Company provides a range of instruments, consumables, software and services that are used for a range of applications in the laboratory, on the production line and in the field. These products and services are used by customers in pharmaceutical, biotechnology, academic, government, environmental and other research and industrial markets, as well as the clinical laboratory. As of December 31, 2016, the Analytical Instruments Segment included three primary businesses: chromatography and mass spectrometry, chemical analysis, and materials and structural analysis.

The chromatography and mass spectrometry (MS) business provides analytical instrumentation for organic and inorganic sample analysis across both applied technologies and life science research. These products are complemented by laboratory information management systems (LIMS); chromatography data systems (CDS); database analytical tools; automation systems; a range of consumables, such as a full line of chromatography columns; and a range of sample preparation and separation products, including auto-samplers and multiplexing systems. Its chromatography product line includes liquid chromatography, ion chromatography and gas chromatography systems, all of which are supported by its Chromeleon chromatography data system software. Its liquid chromatography (LC) Systems analyzes sample matrices in liquids. Its high pressure liquid chromatography (HPLC) and ultrahigh pressure liquid chromatography (UHPLC) systems are used for a range of applications, from complex proteomic analyses to routine industrial quality assurance and quality control. Its ion chromatography (IC) Systems separate ionic (charged) or highly polar molecules, usually found in water-based solutions, and typically detect them based on their electrical conductivity. Its IC products are used in a range of applications, including scientific research, and environmental testing, as well as quality control in pharmaceutical, food and beverage, and other industrial processes.

The Company's gas chromatography (GC) Systems analyze sample matrices in gases, comprising both separation and detection technology. Its GC/MS offering includes a triple stage quadrupole, a single stage quadrupole, an Orbitrap, and an ion trap, for a range of applications, including food safety testing, quantitative screening of environmental samples, and complex molecular analyses. Its elemental analysis spectrometers use atomic spectroscopy techniques to identify trace concentrations of elements in liquid and solid samples primarily in environmental, petrochemical, food safety, metallurgical, geochemical and clinical/toxicology research applications.

The Company's offering includes life sciences mass spectrometry systems; and inorganic mass spectrometry systems, as well as a range of sample preparation and separation products, including auto-samplers and multiplexing systems. Its life sciences mass spectrometers include triple quadrupole, ion trap and Orbitrap technology. Its triple quadrupole systems provide quantitative analysis of chemicals in biological fluids, environmental samples and food matrices. Its ion trap systems are used for in-depth structural analysis of large biomolecules, such as proteins, as well as structural characterization of small molecules, such as drugs and drug metabolites. Its Orbitrap technologies provide high resolution mass capabilities for both research and applied markets and are well suited for drug metabolism, proteomics, environmental analysis, food safety, toxicology and clinical research applications. Its Inorganic Mass Spectrometers include isotope ratio mass spectrometry (IRMS); multi-collector mass spectrometry; inductively coupled plasma mass spectrometry; and high resolution trace mass spectrometry. These products are primarily used for qualitative and quantitative analysis of inorganic matter in a range of applications, including environmental analysis, materials science and earth sciences.

The Company's chemical analysis products fall into four categories: materials and minerals; portable analytical instruments; radiation measurement and security instruments, and environmental and process instruments. Its materials and minerals instruments include production line process monitoring, and control systems for a range of industrial applications.

Specialty Diagnostics Segment

The Specialty Diagnostics segment offers a range of diagnostic test kits, reagents, culture media, instruments and associated products in order to serve customers in healthcare, clinical, pharmaceutical, industrial, and food safety laboratories. As of December 31, 2016, the Specialty Diagnostics segment had six primary businesses, including clinical diagnostics, immunodiagnostics, microbiology, transplant diagnostics and its healthcare market channel.

The Company's clinical diagnostics products include a broad offering of liquid, ready-to-use and lyophilized immunodiagnostic reagent kits, calibrators, controls and calibration verification fluids. The Company provides products used for drugs-of-abuse testing; therapeutic drug monitoring, including immunosuppressant drug testing; thyroid hormone testing; serum toxicology; clinical chemistry; immunology; hematology; coagulation; glucose tolerance testing; first trimester screening; tumor markers testing; and biomarkers testing for sepsis, acute myocardial infarction and congestive heart failure. Its immunodiagnostics offerings include developing, manufacturing and marketing complete blood-test systems to support the clinical diagnosis and monitoring of allergy, asthma and autoimmune diseases. Its microbiology offerings include dehydrated and prepared culture media, collection and transport systems, instrumentation and consumables to detect pathogens in blood, diagnostic and rapid direct specimen tests, quality-control products and associated products for the microbiology laboratory. Its transplant diagnostics products include human leukocyte antigen (HLA) typing and testing for the organ transplant market. Its healthcare market channel offerings include an array of consumables, diagnostic kits and reagents, equipment, instruments, solutions and services for hospitals, clinical laboratories, reference laboratories, physicians' offices and other clinical testing facilities.

Laboratory Products and Services Segment

The Laboratory Products and Services segment offers products needed for the laboratory. It offers controlled temperature technologies products, growth protection and separation products, and water and laboratory products. Its laboratory consumables products include plastics, glass and related equipment. Its global chemicals offers a range of chemicals, solvents and reagents supporting virtually every laboratory application from research to drug discovery and development and manufacturing. This portfolio includes organic chemicals used to synthesize new materials; essential laboratory chemicals used by scientists to purify, extract, separate, identify and manufacture products; analytical reagents, bioreagents used in various applications, from cell growth to detailed protein analysis; chemical building blocks, reactive intermediates and screening libraries used to accelerate drug discovery, and precious metals, salts and solutions used in a range of applications where specific reactions are desired. It also offers scientific support services, including desktop delivery, coordination of instrument calibration and service, and onsite customer service. Its research and safety market channel serves academic, pharmaceutical, biotechnology, government and industrial customers. Its research products include a complete offering of laboratory products, ranging from capital equipment and instruments to chemicals to consumable products. Its safety products include clean-room and controlled-environment supplies, personal protective equipment, firefighting, military, and first responder equipment and supplies, and environmental monitoring and sampling equipment. Its education products include science-related and laboratory products for the Kindergarten-12 (K-12) and secondary education market.